Was this resolved ?
z/OS CMOD 8.4.0.3 had a limit of about 250 Mb input file documented.
The bigger issue was that PDF compression is poor or non-existent for multiple same graphics. We saw PDF file expansion by a factor of 19 (!), so we limited our PDF input files to under 10 Mbs.
In discussion with IBM, we learned that the compression was not resolved until CMOD 8.5. In addition, IBM recommended we index from Windows servers, with final upload to the z/OS server. That gave us the best performance at that time.
We now have a second CMOD system,, v 8.5 on AIX. All our PDFs go to that box, indexed from 5 Windows servers.
On that system, we had load failures of large report PDFs of about 60 Mbs. Bigger problem was that they took forever to load if they needed to be viewed. One user documented a load of one very large PDF at 6 hours. I suggested she might have a network configuration issue.